A Comparative Study of Ondansetron versus Ramosetron on Post Operative Nausea and Vomiting in Gynecological Surgeries
نویسندگان
چکیده
Postoperative nausea and vomiting (PONV) is one of the most unpleasant and distressing symptoms which follow anaesthesia and surgery and lead to serious postoperative complications. PONV commonly occurs within 24 hours after surgery and can occur following general, regional, or local anaesthesia. Patients undergoing major abdominal surgery are especially prone to PONV, with reported incidences of 50-75%. Ninety patients aged between 20-60 years with ASA class I and II, posted for elective abdominal surgeries under spinal anaesthesia were randomly allocated to three groupsGroup O [n=30] Ondansetron (4mg), Group R [n=30] Ramosetron (0.3mg), Group C [n=30] Normal saline(only rescue antiemetic).The incidence of PONV in control group was 40%, while the incidence in Group O and Group R was 16% and 6% respectively. Complete response was observed in 60%, 84% and 94% of patients in Group C, Group O and Group R respectively. The need for rescue antiemetic was significantly reduced with both antiemetic groups compared to control group. Ramosetron was more effective than ondansetron in preventing postoperative nausea and vomiting in patients at high risk undergoing total abdominal hysterectomy.
منابع مشابه
Comparison of Ondansetron V/s Ramosetron for Prevention of Post Operative Nausea and Vomiting in Laproscopic Surgeries (a Study of 100 Cases)
متن کامل
Comparison of ramosetron and ondansetron for control of post-operative nausea and vomiting following laparoscopic cholecystectomy.
BACKGROUND Post-operative nausea and vomiting (PONV) is common. 5HT 3 receptor antagonists are commonly used drugs for its prevention. A study was designed to compare the efficacy and safety of ramosetron and ondansetron in patients undergoing laparoscopic cholecystectomy (lap chole). MATERIALS AND METHODS A prospective randomized case controlled study was conducted at J. N. Medical College H...
متن کامل“A Comparative study of Ondansetron, Granisetron and Ramosetron for Prevention of Postoperative Nausea and Vomiting in Elective middle Ear Surgeries under General Anaesthesia”
Introduction: Postoperative nausea and vomiting (PONV) remains a significant problem in modern anaesthetic practice, with an incidence of up to 80% in high-risk group patients. (1) .This study was aim to evaluate and compare the efficacy of ondansetron , granisetron and ramosetron as prophylactic antiemetic in Elective middle Ear Surgeries under General Anaesthesia . Methodology : 90 patients o...
متن کاملProphylactic control of post-operative nausea and vomiting using ondansetron and ramosetron after cardiac surgery.
BACKGROUND The aim of this study was to evaluate the efficacy of ondansetron and ramosetron in the reduction of post-operative nausea and vomiting (PONV) associated with patient-controlled analgesia (PCA) after cardiac surgery. METHODS A total of 320 patients scheduled for elective cardiac surgery were enrolled. Patients were randomly assigned to one of four treatment regimens (n=80 in each g...
متن کاملOndansetron and Aprepitant Vs Ondansetron alone in prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgeries: A comparative study
Recent studies have shown that aprepitant, a substance – P/ Nk 1 receptor antagonist is effective in postoperative vomiting. The present study was designed to find out whether addition of aprepitant to ondansetron would be more effective than ondansetron alone in prevention of post operative nausea and vomiting in patients undergoing laparoscopic surgeries. After obtaining informed consent, 50 ...
متن کامل